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Evolution and phylogenetic distribution of SLC22A4 Phylogenetic analyses (201,202) indicate that homologues of SLC22A4, a relative of the major facilitator superfamily 2, exist only in vertebrate animals, especially mammals, birds and fish, with occasional examples in reptiles (for example, Xenopus spp.)

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In the nine-quadrant analysis, quadrant Q3 (concordant upregulation) contained only three genes, all belonging to the selenoprotein family: SELENOW , SELENOP , and GPX1

This requires the association of LPS to a specific binding protein, LPS-binding protein (LBP)

In IH treated neuron model, Tanshinone IIA could inhibit oxidative stress and neuronal apoptosis by activating autophagy [42]

Respiratory / ENT: Congestion of the nose, sneezing