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Aggregated peptides lose their ability to bind the FOXO4-p53 interface, rendering the solution biologically inactive

Activation and nuclear translocation of the primary transcription factor Nrf2 promote the expression of these enzymes, providing robust protection against oxidative damage [44]

Liposomal glutathione is a glutathione supplement enclosed in phospholipid liposomes that assists with stability and absorption

In addition, the simultaneous use of DSF and cisplatin (GC) altered the cellular distribution of the GC efflux transporter ATP7A, enhanced the formation of DNAplatinum adducts, and facilitated apoptosis (Kita et al., 2019)

These rates dropped to 52% during the last 2 weeks of treatment for the disulfiram group and to 71% for the placebo group ( F = 6.982, d f = 1,134, p = 0.009 with an effect size of 0.0495)