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Statements Author contributions CP and TZ designed and conceptualized this paper

10.1038/s41467-023-37269-3

A recent study even suggested that the Friedewald equation tends to underestimate LDL-C among people with low LDL-C if triglyceride levels are moderately elevated ( 150 mg/dl) (6)

Sustained UPR can promote the development of MAFLD by regulating lipogenesis, causing inflammation, and inducing hepatocyte death (Lebeaupin et al., 2018

This leads to Pink1 accumulation on the OMM, which promotes the recruitment of the E3 ligase Parkin to mitochondria [275, 276]

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