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Huang X, Gao L, Deng R, et al

Several examples have also now emerged suggesting the GH/IGF-1 signaling pathway is relevant to human aging 12 , including the discovery of functional mutations in the IGF-1R gene in individuals with exceptional longevity, resulting in relative IGF-1 resistance 13,14 , and in subjects lacking functional GH receptors (Laron dwarfs) 15

Therefore, infection is not the only cause of inflammation

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In this study, H 2 O 2 stimulation led to a significant upregulation of DKK3 expression in SRA01/04 cells, exhibiting a time-dependent trend

In senescence, microglia and macroglia acquire a state of chronic activation that results in an autoimmune response, neuroinflammation and altered BRB, ultimately leading to neurodegeneration (Xu et al., 2009