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Glyoxalase-1-dependent methylglyoxal depletion sustains PD-L1 expression in metastatic prostate cancer cells: a novel mechanism in cancer immunosurveillance escape and a potential novel target to overcome PD-L1 blockade resistance

Front Endocrinol (Lausanne) 16:1520835 Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K et al (2023) Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging

In diabetic ApoE / mice, ebselen treatment was also shown to be beneficial

Q.et al (2011b)

The ability of fumarate to non-enzymatically react with the sulfhydryl of cysteine residues in proteins, in a reaction referred to as Michael addition, generates a 2-(succino)cysteine (2SC) residue

Shengli J, Shengnan Q, Yan G, Zhiying W
