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doi: 10.1111/bjh.12959

Aging Aggravates Intervertebral Disc Degeneration by Regulating Transcription Factors toward Chondrogenesis

Tissue-engineered intervertebral discs produce new matrix, maintain disc height, and restore biomechanical function to the rodent spine

Molecular Information (Individual Components) BPC-157 CAS: 137525-51-0 Molecular Formula: C 62 H 98 N 16 O 22 Molecular Weight: 1419.54 g/mol TB-500 (Thymosin Beta-4 Fragment) CAS: 77591-33-4 Molecular Formula: C 212 H 350 N 56 O 78 S Molecular Weight: 4963.49 g/mol Research Applications Cell migration and cytoskeletal signaling pathway studies Peptide-mediated cellular interaction modeling Angiogenesis and vascular signaling pathway research Investigations involving epithelial cell signaling mechanisms in controlled laboratory models Disclaimer: For laboratory research use only

Studies carried out using epithelial cell lines and animal models showed that gliadin was able to induce apoptosis of intestinal epithelial cells through a direct toxic effect (251), including enterocyte atrophy, villi shortening, decreased epithelial disaccharidase activity, increased expression of HLA molecules, and intraepithelial inflammatory activation

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