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In the present study, we combine untargeted proteomics with an optimized tear fluid proteomics workflow, including in-strip protein digestion, which has previously identified over 3000 unique proteins in tear fluid 21

At therapeutic doses, healthy livers detoxify NAPQI by phase II conjugation with glutathione (GSH) to form inert mercapturate and cysteine metabolites

doi: 10.2174/0929867321666131201144612

2021 October 7

In addition, small molecule inhibitors including SLC7A11 inhibitor HG106 and GCLC inhibitor buthionine sulfoximine (BSO) were introduced to investigate their effects on ROS, GSH levels and cellular viability in VRK2-KO and VRK2-KD cells, and the results were consistent with the above knockdown experiment (Fig