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NIH has already announced a few changes to the SBIR/STTR program: NIH will now be accepting Direct-to-Phase II STTR awards

FDA GRAS determination (2007): The FDA reviewed AOD-9604's toxicology data and granted Generally Recognized As Safe status for oral use as a food ingredient

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TABLE 1 Influence of probiotic bacteria on tight junction proteins

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This has been supported by the demonstration of a decrease in serum citrulline in these patients [63]