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Homocysteine Homocysteine is another way to assess Vitamin B12 levels, it is not as specific as MMA because high homocysteine levels can also indicate a deficiency in B2, B6, folate, and B12

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There are several overlapping mechanisms that can produce the same visible result

Acta Biochim Biophys Sin (Shanghai) (2021) 53(6):66372

While I usually recommend the methylated version of B12 (such as the one by Pure Encapsulations), individuals with the COMT genetic SNP may benefit more from the hydroxy- or adeno- forms of B12

10.1164/rccm.200606-778oc Am