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I have read claims that B12 is a general detoxifier but there is limited research supporting its direct action as a detoxifer

Metabolic optimization is always approached as a system, not a single solution

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Symptoms of vitamin B-12 deficiency include: Fatigue Difficulty concentrating Decreased mood Loss of appetite Poor memory Constipation Higher-risk groups for vitamin B-12 deficiency include people with intestinal disorders such as Crohns or Celiac disease, as well as those who suffer from muscular degeneration, Lou Gehrigs disease or diabetes

If left untreated, the deficiency can cause severe neurologic problems and blood diseases

Some practitioners consider combination protocols, though this approach lacks specific research validation