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Malaguarnera, Mariano, et al

Some people have a mutation in the gene that controls this enzyme, which prevents it from breaking down certain chemicals properly

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This hypothesis might be supported by the assumption that, contrary to severe vasculogenic ED, ED of mildmoderate degree might reflect a less extensive and/or more recently occurred vascular damage, which might be partially reversible and, therefore, more likely to respond to l-ARG supplementation, although this speculation needs objective confirmation

We would suggest doing your own reading of both sides of the argument here before making any conclusions