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Acknowledgments This work was supported by a Discovery Project Grant from the Australian Research Council (ARC

4.3 Regulation of serum metabolites and hepatic metabolites in bullfrogs by glutathione In the serum metabolomics and liver metabolite assay of bullfrogs, it was found that the significant differential metabolites in the three comparisons were mainly lipids and lipid-like molecules, as well as some organic acids and their derivatives

Glutathione is a highly potent antioxidant

Residue on ignition [sulfated]: 0.10% max

Start low: Begin around 250 g daily for 12 weeks Increase gradually: Up to 500 g twice daily if tolerated Cycle: 46 weeks on, then take 24 weeks off This approach supports tendon, muscle, or ligament healing without overloading the system

These interconnected systems contribute to inter- and intra-individual heterogeneity in metabolic phenotype