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Annals of Oncology
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[DOI] [PubMed] [Google Scholar] 95.Fitzpatrick A.M., Teague W.G., Burwell L., Brown M.S., Brown L.A
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In these assays, CuCl 2 alone showed no activity up to 250 M, whereas Cu 3 -TC-Py consistently produced IC 50 values in the 10-30 M range and Cu 3 -TC-Thio in the 30-60 M range
An overproduction of ROS leads to mitochondrial dysfunction, DNA damage, and chromosomal aneuploidy, especially in women of advanced reproductive age, thereby diminishing oocyte quality
