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Depending on the situation, other medical treatments for lip discoloration or lesions may include: laser therapy light therapy chemical peels cryotherapy medicated ointments, such as 5-fluorouracil and Solaraze A 2018 systematic review in the aloe vera gel niacinamide green tea extract turmeric vitamin C However, the authors note that many of the studies were not large-scale clinical trials, and so more research on this is necessary

Plus, the serums packaging is both airtight and completely opaque things Gonzalez says you should look for when choosing a serum, because packaging like this helps to keep the vitamin C away from exposure to water, light, and oxygen (all of which degrade it)

For my elbows, wrists, knees and ankles, I use a brush to buff in the product and help blend it out

These treatments are often more intensive and can deliver faster, more noticeable results, especially for stubborn or deep-seated post-inflammatory hyperpigmentation (PIH)

Future treatment strategies should integrate genotype-specific resistance profiling with immune-modulating approaches to limit RAS selection and improve patient outcomes