glutathione and friedreich's ataxia Deciphering the ferroptosis pathways in dorsal root ganglia of Friedreich models. The role of LKB1/AMPK, KEAP1, GSK3β in the impairment of the NRF2 response Friedreich's ataxia symptoms | Friedreich's

doi: 10.3389/fnagi.2021.745046, 86 MajernkovN.Marmolejo-GarzaA.SalinasC

Cadmium [25], lead [68], and mercury [912] have no essential biochemical roles, but exert diverse, severe toxicities in multiple organ systems as they bind in tissues, create oxidative stress, affect endocrine function, block aquaporins, and interfere with functions of essential cations such as magnesium and zinc

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Cell death may result from lipid peroxidation brought on by iron excess

[nature] 23

In thyroid diseases, metabolic disorders associated with low-grade inflammation can also lead to an increased oxidative stress (68)