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The Regulatory Mechanisms of Ferroptosis Ferroptosis is a ROS-dependent form of cell death associated with the accumulation of excessive iron and lipid peroxidation, as well as changes in specific genes involved in regulating iron homeostasis and lipid peroxidation metabolism (Yan et al., 2021)

Activation of AP with iron and ascorbate was tested in air-saturated buffer

Results vary depending on age, genetics, lifestyle, physical activity, stress, and baseline depletion

Mycorrhizal fungi, particularly ectomycorrhizal (ECM) species like Boletus, Amanita , and Laccaria , form symbiotic associations with tree roots that enhance nutrient exchange and carbon sequestration in forest soils (Nuralykyzy et al., 2025)

Roh's group found a lead compound ( 120 , Figure 24 ) with a thiazolidine-2,4-dione skeleton and its potential in the inhibition of IKK (IC 50 = 1500 nM), therefore, they tried to optimize this core via exploring the electron push-pull effect of the right moiety and analyze the SAR [194]