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Therefore, DHODH has emerged as a potential regulatory hub, where its inhibition may enhance ferroptotic cell death, offering a novel angle for therapeutic intervention, particularly in cancers such as pancreatic adenocarcinoma (175) and breast cancer (176), where certain cells show resistance to other forms of cell death (171,177)

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Even if antioxidant defense is significantly increased and oxidative stress markers are reduced, antioxidant treatment may have no significant impact on disease progression [161]

Although, it is important to note that the overall outcome of both animal and human studies seems to be mixed

The compound's interaction with GABA receptors and nitric oxide signaling provides a protective effect against oxidative stress-induced neuronal damage