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Cyclodextrin-based host-guest complexes loaded with regorafenib for colorectal cancer treatment

Chembiochem 20 , 103110 (2019)

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Frataxin is a small protein that contains an acidic surface that can bind several ferrous iron atoms, whereas other surfaces enable Frataxin to bind the scaffold protein, ISCU, or the heme biosynthetic enzyme, Ferrochelatase, thus potentially allowing Frataxin to readily donate ferrous iron for incorporation into nascent FeS clusters as they are assembled on ISCU [13,34]

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