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In summary, through pan-cancer analysis using the TIMER database combined with mechanistic integration, this review demonstrates that the activation patterns of the serine synthesis pathway (SSP) in malignant tumors are not randomly distributed, but follow three distinct molecular subtypes: driver mutation-dependent, microenvironmental stress-adaptive, and epigenetic dysregulation subtypes

This can be broadly sub-grouped as related to gastrointestinal [74] and metabolic disorders [174]

By controlling Mn 2+ , MnO 2 NPs can also activate cGAS-STING signaling pathway to trigger adaptive immune responses through the antigen presentation by APCs

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Fumarate induces redox-dependent senescence by modifying glutathione metabolism

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