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Elevated expression of IGF-2 is also associated with increased risk of breast cancer development and has been implicated in disparities in breast cancer risk and survival outcomes in African American women [70,71]
Cell 65 , 1068-1080.e5 (2017)
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Low B vitamin intake, especially B12, is a common contributor to persistent low energy that caffeine can't fix
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IGF1 LR3s longer half-life makes it more suitable for systemic effects and sustained receptor start, while IGF-1 DESs shorter half-life may be advantageous for more localized or acute effects
