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Iron accumulation not only directly damages cardiomyocytes but also exacerbates mitochondrial damage through the promotion of lipid peroxidation (97)

ROS levels determine the sensing of pathogens by neutrophils and their subsequent activation of NLRP3 inflammasome and cytokine synthesis (88)

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Studies show GSNO administration increases wound collagen content by 52.0% at day 5 and 47.5% at day 10 compared to controls, while maintaining physiological collagenolytic activity necessary for proper tissue remodeling

The concept of "normal" is based on the middle 95% of results, fitting within a typical bell-shaped curve

12 and Supplementary Fig