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Pathway 1 GLP-1 (Retatrutide) GLP-1 receptor activation in the hypothalamus and nucleus of the solitary tract (NTS) drives appetite suppression and slowed gastric emptying

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This buildup is thought to trigger downstream effects, including the formation of tau-containing neurofibrillary tangles, due to an imbalance between A production and clearance

[DOI] [PMC free article] [PubMed] [Google Scholar] 236.Pshezhetsky AV, Richard C, Michaud L, Igdoura S, Wang S, Elsliger MA, Qu J, Leclerc D, Gravel R, Dallaire L, and Potier M

[DOI] [PMC free article] [PubMed] [Google Scholar] 298.Tlak Gajger I., Ribari J., Smodi kerl M., Vlaini J., Sikiri P