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Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2

All IgG variants or recombinant Fc fragments were produced in HEK293E cells or Expi-CHO (Humab 2C7) by transient transfection using Lipofectamine 2000 (ThermoFisher)

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However, recent studies (2026) have shown that the mitochondrial pyruvate carrier (MPC) complex is involved in the mitochondrial export of lactate

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Changes in brain structure and function are observed in individuals with high-functioning autism