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demonstrated that ferroptosis, accompanied by decreased FNDC5 expression, occurs in both STZ-induced type 1 diabetic mouse bone tissue and high glucose-exposed MC3T3-E1 cells, with irisin administration or FNDC5 overexpression ameliorating type 1 diabetic bone loss via inhibition of endoplasmic reticulum stress-mediated ferroptosis [177]

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Phagocytic leucocytes (white blood cells) especially neutrophils produce abundant of oxygen radicals through NADPH-Oxidase activity (O2 + e O2) as effort to destroy invading pathogens in defense or protection of the host organism.11 Oxygen-derived radicals are also produced as integral metabolites in cascades of enzyme catalyzed reactions

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