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In guinea pigs, adrenal AA has been observed to exert a modulating role over the production of adrenal steroids during stress, 115 and AA deprivation is associated with a sharp rise in plasma corticosteroid concentrations

EGCG has shown potential in treating AD by targeting multiple pathological aspects

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Herbette S, Lenne C, Leblanc N, Julien J-L, Drevet JR, Roeckel-Drevet P (2002) Two GPX-like proteins from Lycopersicon esculentum and Helianthus annuus are antioxidant enzymes with phospholipid hydroperoxide glutathione peroxidase and thioredoxin peroxidase activities

In recent years, diversity, equity, and inclusion (DEI) have become essential focus areas in clinical trials, with a primary goal of increasing participant diversity

The large size of the NF1 gene, the presence of homologous pseudogenes in pericentric regions of other chromosomes, the limited genotype-phenotype correlation, and the absence of hotspots make study of mutations laborious and costly