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However, one school of thought maintains that inclusion of placebo subjects in FIH trials, which are underpowered, is not justified or useful.33 Most AEs observed in FIH studies are just reported as probably related with minimal interpretation of causality and more serious AEs are typically followed with greater diligence and concern

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Therefore, investigating endogenous HDAC expression and regulation within specific cell types during aging and AD is essential to elucidate their distinct roles and influence on cognitive processes in physiological and pathological states

doi: 10.3389/fnagi.2022.986443 32 LiY.WuM.KongM.SuiS.WangQ.HeY.et al

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