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When bile becomes supersaturated with cholesterol, gallstones precipitate

The treatment regimen consisted of a weekly dose of 16mg/kg for the first two cycles (8 weeks), followed by biweekly doses for the next 16 weeks (cycles 3-6), and then monthly doses thereafter

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3 Another study showed that vitamin B12 levels were significantly lower after 4 months of treatment with isotretinoin for acne vulgaris
