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10.1038/nm.4010 [DOI] [PMC free article] [PubMed] [Google Scholar] 27.Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, OHara SP, LaRusso NF, Miller JD, et al

doi: 10.1016/j.cmet.2015.02.013 19 BenayounBALeeC

Consistent with an iron-sulfur cluster defect, SLC25A39/40 knock out cells displayed reduced activity of the enzyme aconitase, in which iron sulfur clusters function in both substrate binding and catalysis (Fig 4f)

So far, the role of GSTs in the detoxification of reactive intermediates of clozapine, a drug-causing idiosyncratic drug reactions (IDRs), has not been studied

In this review, we highlight current knowledge of these functions, and discuss the potential future direction of new studies, and how these pathways may be targeted in future pre-clinical studies
