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It has been demonstrated that NO interacts as a ligand to form transition metal complexes with iron and glutathione (GSH), resulting in dinitrosyldithiol-iron complex (DNICs) formation, which is important for many physiological functions [15]
Table 1 Key metabolic pathways, targets, and metabolite alterations involved in RA pathogenesis

3.5 Heavy metals and coagulation mechanisms in ischemic stroke Heavy metal interfere with platelet function, coagulation, and the fibrinolytic system through various mechanisms, thereby affecting thrombus formation (Figure 6)
More interestingly, the treatment of mice with the GluN2B antagonist ifenprodil (2.5 mg/kg body weight) prevented the growth of PanC-1 tumor xenografts and decreased the tumor size by almost half, indicating that ifenprodil is more effective in the inhibition of NMDAR in vivo (107)

The same trend was noted for GPX-like genes (especially for GPX6 and GPX8 ) (Fig