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Single-nucleus RNA sequencing (snRNA-seq) has identified a subpopulation of BM adipocytes involved in thermogenesis (94)

Early and smaller studies suggested effects on fat metabolism and body fat distribution, but larger obesity trials did not show a robust, clinically meaningful weight loss outcome on their own

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These recombinant reagents use two heavy chains that react with distinct epitopes of the same molecule

Treatment focuses on addressing the underlying cause, controlling symptoms, and preventing complications particularly foot injuries in patients with diabetes who cannot feel pain normally

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