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Furthermore, many lipidomic studies have demonstrated that PD-specific lipids are significantly altered in the brains and plasma of patients with PD, such as alterations in the lipid composition of lipid rafts in the frontal cortex

Puente C, Hendrickson RC, Jiang X

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Berberine modulates cancer immunity, reduces drug resistance, promotes apoptosis and autophagy, inhibits cell cycle progression, and curtails invasion and metastasis in a range of cancers such as lung, breast, colon, liver, gastric, prostate, ovarian, and leukemia [194, 195]

Figures 1B , 3 ) is not fully ameliorated by conventional subcutaneous insulin administration, most likely because subcutaneous administration of insulin cannot fully compensate for the normal portal delivery of insulin to the liver

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