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Under normal conditions, Keap1 complex-mediated ubiquitination degrades Nrf2, and when confronted with oxidative stress, Keap1 complex activity is inhibited and the Nrf2/ARE pathway is activated

doi: 10.1096/fj.02-0566fje

Conclusions Astrogliopathology is complex, heterogeneous and context dependent with regard to disorder, disorder-stage, comorbidities, age, and sex

Abbreviations AS: Alternative splicing CDNB: 1-Chloro-2,4-dinitrobenzene ES: Exon skipping GS-DNB: S-(2, 4-dinitrophenyl)-glutathione GSH: Glutathione GST: Glutathione S-transferase IR: Intron retention KEGG: Kyoto Encyclopedia of Genes and Genomes MAFFT: Multiple alignments using fast Fourier transform MeJA: Methyl jasmonate ML: Maximum likelihood MW: Molecular weight NCBI: National Center for Biotechnology Information ORF: Open reading frame pI: Isoelectric point ROS: Reactive oxygen species TSS: Transcription start sites TTS: Transcription terminal sites UTRs: Untranslated regions References Basantani M, Srivastava A