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Hawkins N, Golding J
The most advanced of the prodrug candidates is TLK286, -glutamyl- -amino- -(2-ethyl- N , N , N , N -tet-rakis (2-chloroethyl) phosphorodiamidate)-sulfonyl-propionyl-( R )-() phenylglycine)
By upregulating VEGFR2 signaling, the compound promotes the formation of new blood vessels in damaged tissue a process called angiogenesis
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