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3.2.4 Ferroptosis and amyotrophic lateral sclerosis ALS is a lethal NDD characterized by progressive degeneration of upper and lower motor neurons in the cerebral cortex, brainstem, and spinal cord, leading to skeletal muscle atrophy, weakness, weight loss, dysarthria, dysphagia, paralysis, and ultimately death from respiratory failure (Feldman et al., 2022)

Perilesional astrocytic border (again contrary to a widespread beliefs) is permissive for axonal outgrowth and tissue recovery

2018 Apr 26;10(5): PMID: 29534031

Metformin is a drug used to treat type 2 diabetes mellitus and to help prevent type 2 diabetes in patients at high risk of developing it

Kirenol (2 mg/kg