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gallinarum DNA detected in biopsy samples obtained from both SLE and autoimmune hepatitis patients (Manfredo Vieira et al

Huang X, Yao J, Liu L, Chen J, Mei L, Huangfu J, Luo D, Wang X, Lin C, Chen X, Yang Y, Ouyang S, Wei F, Wang Z, Zhang S, Xiang T, Neculai D, Sun Q, Kong E, Tate EW, Yang A

While certain senolytic compounds have shown specificity for senescent cells in preclinical models, achieving this selectivity in humans remains a significant hurdle.120 For example, some senescence-associated proteins (eg, BCL-2, p53, SASP factors) are also expressed in normal, proliferating cells, leading to potential off-target effects.31 Therefore, optimizing senolytic agents to minimize side effects while maintaining efficacy is crucial

Exogenous source L-serine can be obtained through dietary intake

TfR1 expression in SH-SY5Y-APP Swe/Ind cells was further validated by immunofluorescence staining (Supplementary Figures 2C and D)

During oxidative phosphorylation, a small fraction of electrons leaks from Complexes I and III of the electron-transport chain, reducing molecular oxygen to superoxide (O)