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Oxidative stress was reported to induces autophagy and cell death in RPE cells [167, 168]

It turned out that some types of cancer can be intrinsically refractory to antiangiogenic therapy or during the treatment acquire resistance to anti-VEGF agents (103,104)
doi: 10.1016/j.phrs.2007.01.009 41

Hypolipidemic Activity Abnormally high levels of lipids or fats can cause hyperlipidemia, a chronic disease that elevates the risk of heart disease and stroke (59)

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