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Group 3 (PPA + Quercetin [PPAQ], n = 10): This group was induced with PPA and then treated with 80 mg/kg/day quercetin (abcam, ab120247, Cambridge, UK) by oral gavage

552 M1-mAChR positive allosteric modulators (M1-PAMs), such as BQCA ( 53 ) and PF06764427 ( 54 ), achieve subtype selectivity through allosteric effects but have significant agonistic activity that may lead to side effects like diarrhea

And if it spreads to the rest of the GI tract, it can cause digestive issues and dysbiosis

Pan S, Wei H, Yuan S, Kong Y, Yang H, Zhang Y, Cui X, Chen W, Liu J, Zhang Y (2022) Probiotic Pediococcus pentosaceus ameliorates MPTP-induced oxidative stress via regulating the gut microbiota-gut-brain axis

If you are exploring evidence-based regenerative strategies, BPC-157 peptide therapy may be worth a thoughtful conversation with your healthcare provider

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