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In this respect, an interesting study conducted on immortalized human microglia cells (CVCL_5G94) highlighted how ATRAs can increase the heat shock protein 90 (Hsp90) expression on the surface of these cells, causing an increase in the amount of endocytosed and consequently eliminated tau protein (25)

And over time, weight regain becomes more likely

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Nutritional interventions also play a key role in secondary prevention, though their implementation in postoperative care remains inconsistent (Hotta et al., 2021)

Kupffer cells in the liver respond to alterations in lipid accumulation and can activate inflammatory pathways [42], that then can drive NASH progression