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UC, ulcerative colitis NF-B, nuclear factor kappa-B IKK, inhibitor of nuclear factor-B (IB) kinase IB, inhibitor of nuclear factor kappa-B GIT, gastrointestinal tract ROS, reactive oxygen species CAT, catalase GPX, glutathione peroxidase SODs, superoxide dismutase SCFA, short-chain fatty acids HOCl, hypochlorous acid H 2 O 2 , hydrogen peroxide ETC, electron transport chain COXs, cyclooxygenases NOS, nitric oxide synthase MPO, myeloperoxidase XO, xanthine oxidase NOX, NADPH oxidase IECs, intestinal epithelial cells ICAM, intracellular adhesion molecule NF-kB, nuclear factor-kappa B CAMs, complementary and alternative medicines APC, antigen-presenting cells TNF-, tumor necrosis factor- IL-1, interleukin-1 RCTs, randomized controlled trials Abbreviations References 1

Acknowledgments Purified olive mill waste water extract A009 and OliPhenolia was provided by Fattoria La Vialla di Gianni, Antonio e Bandino Lo Franco SAS (Castiglion Fibocchi, Arezzo, Italy)