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The disruption of the ER and induction of the unfolded protein response (UPR) by SARS-CoV-2 has been described by several authors (5, 6)

however, chronic and uncontrolled inflammation can cause extensive tissue damage [72]

Noncontrast brain CT showed mild brain atrophy with chronic small vascular disease

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4.6 Improvement of microcirculation PNS can significantly improve microcirculation of brain tissue, its main mechanism of action is to increase blood flow to the brain by dilating blood vessels, thus improving blood supply to brain tissue