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Description
J Regen Biol Med

[11] Long-term metformin therapy reduces calcium-dependent intrinsic-factor binding, lowering B12 absorption and potentially necessitating higher or more frequent parenteral doses

Cyanocobalamin is a little different

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It is optimized for laboratory preparation compatibility with sensitive research compounds without altering receptor pathway research variables

But all that work can be undone in seconds with a sloppy reconstitution
