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This multidimensional dysfunction challenges reductionist treatments, necessitating a systems-based approach

[DOI] [PubMed] [Google Scholar] 69.Moi P., Chan K., Asunis I., Cao A., Kan Y.W

A recent study unveiled the depletion of GPX4 in postmortem spinal cord samples from both sporadic and familial ALS patients, revealing a potential involvement of GPX4 in the pathogenesis of ALS [489]

In general, these enzymes catalyze the transfer of sulfonate (SO 3 ) from the universal sulfonate donor 3phosphoadenosine 5phosphosulfate (PAPS) to the hydroxyl or amino group of an acceptor molecule, Fig

Sundararaj, S