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Cagrilintide primarily activates amylin receptors 1 and 3 (AMY1R and AMY3R) in the brain specifically in the area postrema and nucleus of the solitary tract

[49] Post-marketing worldwide reports in patients receiving oral ketoconazole have included rare cases of paresthesias, and signs of increased intracranial pressure including bulging fontanelles and papilledema

CGRP binds to CLR receptors on osteoblast cell surfaces, directly enhancing osteogenic gene expression

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10.1016/S1360-1385(00)01601-0 43 EdwardsR.DixonR