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On the other hand, AR also utilizes NADPH to convert glucose to sorbitol, which depletes intracellular NADPH, making GSSG irreducible and promoting oxidative stress 18

Int J Biol Macromol 185:679687

The present review summarizes ferroptosis-related mechanisms across AD, PD and DACI, emphasizing both the common molecular features and the unique triggers in each disease
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