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One of the approaches to enhance soluble expression is co-expression of protein chaperones [14]

Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via AP-1 and NFB

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[DOI] [PubMed] [Google Scholar] 67.Fukushige S., Horii A

Change in CYP2E1 and PDI protein levels It is known that CYP2E1 is an important hepatic drug-metabolizing enzyme that converts APAP to a hepatotoxic metabolite (NAPQI), and lack of CYP2E1 would make the mice insensitive to APAP-induced hepatotoxicity

This stability is relevant to research protocol design, particularly in protocols involving extended storage or varied conditions