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To minimize systemic release of the potent payload in human plasma, IKS03 incorporates a linker cleavable by the lysosomal enzyme beta-glucuronidase

2001 Dec;142(12):5182-9

If it's not, you might have a problem

[DOI] [PubMed] [Google Scholar] 73.Pettinati I., Brem J., McDonough M.A., Schofield C.J

Duffy, David C.Lab on a Chip (2013), 13 (15), 2902-2911CODEN: LCAHAM
