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Influence of metabolism on epigenetics and disease
By inhibiting NNMT and preserving NAD, 5-Amino-1MQ indirectly boosts SIRT1 activity , leading to: Increased fat oxidation SIRT1 activates PGC-1 (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), a master regulator of mitochondrial biogenesis and fat metabolism
[DOI] [PubMed] [Google Scholar] 18.Pederson RABJ
FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells
Leiss et al
10.3109/s10165-011-0500-1 31
