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Both basic and clinical studies have provided evidence that glutathione deficiency not only participates in pathology, but its replacement offers an opportunity for powerful therapeutic intervention

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The two enzymes are -C3-hydroxylase [-carotene (-carotenoid) 3,3-hydroxylase] and -C4-ketolase [-carotene (-carotenoid) 4,4-ketolase (oxygenase)], and facilitate multistep hydroxylation and ketolation (oxygenation) reactions at the C3 and C4 positions of the -ionone ring (-end group), respectively (Figure 8) [37]

Benefits of HRT for Aging and Health: Increased energy levels: Feel more vibrant and less fatigued