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[PMC free article] [PubMed] [Google Scholar] 69.Buonocore D., Grosini M., Giardina S., Michelotti A., Carrabetta M., Seneci A., Verri M., Dossena M., Marzatico F

Activation of ER can inhibit NF-B and NLRP3 inflammasome signaling pathways, reduce the release of inflammatory factors such as IL-6 and TNF-, thereby reducing vascular endothelial inflammation ( Although a large amount of evidence supports that estrogen has a protective effect on the cardiovascular system, the clinical application of its alternative therapy (ERT) is still controversial

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10.1016/j.celrep.2024.114237 125 TerseyS

The goals and opportunities for supporting brain health may also differ between midlife and older adulthood

However, surgery has its risks, including death and disability, so that even for large or paraesophageal hernias, watchful waiting may, on balance, be safer and cause fewer problems than surgery