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We demonstrated that the GSH synthesis inhibitor buthionine sulfoximine (BSO) synergistically enhanced L-PAM activity (inducing 24 logs of cell kill) against nine MM cell lines (also in the presence of marrow stroma or cytokines) and in seven primary MM samples (combination indices <1.0)

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Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity

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